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Ethics of Therapeutic Use of Induced Human Pluripotent Stem Cells

Ford, Norman (2012) Ethics of Therapeutic Use of Induced Human Pluripotent Stem Cells. Ethics Education, 18 (1 and 2). pp. 5-22. ISSN 1444-8386

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Abstract

Towards the end of 2006 Dr. Shinya Yamanaka and Dr Kazutoshi Takahashi found a method to convert differentiated adult mouse cells into pluripotent stem cells," In the following year they reported more findings: "Human iPS cells were similar to human embryonic stem CES) cells in morphology, proliferation, surface antigens, gene expression, epigenetic status of pluripotent cell-specific genes, and telomerase activity'"

This scientific breakthrough showed that it was possible to reprogram somatic cells back to the pluripotency stage by modifying a few key transcription factors.' These reprogrammed cells are known as induced pluripotent stem cells (iPSCs) and they "exhibit the morphology of embryonic stem cells and resemble them in many ways, including maintaining their developmental potential to differentiate into derivatives of all three primary germ layers. Up to then, the only available sources for stem cell therapy were bone marrow and umbilical cord derived stem cells,"

Scientists want to find and study the genes which act as master regulators of chromosomes' genes by turning them on and off in skin cells or other tissues to modify cells' behaviour. They worked in their laboratory to discover which genes could reprogram adult cells into stem cells and how human genes could produce pluripotent stem cells without using human embryos.'

Item Type: Published Articles
Repository Version: Author's Final Manuscript
Keywords: Human Pluripotent Stem Cells, Dr. Shinya Yamanaka, Dr Kazutoshi Takahashi, IVF,
Fields of Research: 22 Philosophy and Religious Studies > 2201 Applied Ethics > 220101 Bioethics (human and animal)
22 Philosophy and Religious Studies > 2201 Applied Ethics > 220106 Medical Ethics
22 Philosophy and Religious Studies > 2203 Philosophy > 220305 Ethical Theory
Socio-Economic Objective: C Society > 95 Cultural Understanding > 9504 Religion and Ethics > 950401 Bioethics
Type of Activity: Pure Basic Research
Subjects: D - Ethics / Moral Theology
A - Philosophy
College/Association with University of Divinity: CTC: Catholic Theological College
Depositing User: Rev Prof Norman Ford
Date Deposited: 23 Oct 2013 02:50
Last Modified: 23 Jun 2014 02:39
URI: http://repository.divinity.edu.au/id/eprint/1256

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